Glybenclamide
Data Sheet
For research use only. Not for human use.
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| CAS No. | 10238-21-8 | Cat. No. | BCP05327 |
| Name | Glybenclamide | ||
| Synonyms | Glyburide; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H28ClN3O5S | M. Wt | 494 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glibenclamide, a sulphonylurea oral hypoglycaemic agent is a widely used antagonist of cromakalim-activated K+ channels in smooth muscle. Binding of Gli to SUR produces the closure of KATP channels and the inhibition of their activity. Glibenclamide is widely used for treatment of type 2-diabetes and it has been signaled as antiproliferative in several tumor cell lines. | ||
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