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GK921 Chemical Structure

GK921

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20748CAS No. ：1025015-40-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1025015-40-0 Cat. No. BCP20748
Name GK921
Synonyms GK-921; GK 921;
SMILES
Chemical Name
Formula C21H20N4O M. Wt 344.42
Purity 98% Storage Store at 4-8°C
Description GK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0.905 μM). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC.
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