GDC0980

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02622CAS No. ：1032754-93-0Purity：99%

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CAS No.	1032754-93-0	Cat. No.	BCP02622
Name	GDC0980
Synonyms	GDC-0980;GDC 0980;RG 7422;RG-7422;RG7422; GNE 390; GNE-390; GNE390; Apitolisib;
SMILES
Chemical Name
Formula	C23H30N8O3S	M. Wt	498.6
Purity	99%	Storage	Store at 4-8°C
Description	GDC-0980 shows the potent and selective inhibitory activities against class I PI3K and mTOR kinase versus a large panel of kinases with Ki of 17 nM for mTOR and IC50 of 5 nM, 27 nM, 7 nM, and 14 nM for PI3Kα, β, δ, and γ, respectively.In vitro, GDC-0980 significantly inhibits cell proliferation in PC3 and MCF7 cells with IC50 of 307 nM and 255 nM, respectively. A recent study shows that GDC-0980 reduces cancer cell viability by inhibiting cell-cycle procession and inducing apoptosis with most potency in prostate (IC50 < 200 nM 50%), <500 nM 100%), breast (IC50 <200 nM 37%, <500 nM 78%) and NSCLC lines (IC50 <200 nM 29%, <500 nM 88%) and less potency in pancreatic (IC50 <200 nM 13%, <500 nM 67%) and melanoma cell lines (IC50 <200 nM 0%, <500 nM 33%).