Sumatriptan succinate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 103628-48-4 | Cat. No. | BCP05168 |
| Name | Sumatriptan succinate | ||
| Synonyms | GR 43175;Imigran;Imitrex; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H27N3O6S | M. Wt | 413.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sumatriptan succinate is a serotonin1 (5-HT1) receptor agonist, which is effective in the acute treatment of migraine headache. Its antimigraine activity is believed to derive from selective vasoconstriction of cranial blood vessels which are dilated and distended during migraine headache and/or from inhibition of neurogenically mediated inflammation in the dura mater . For sumatriptan succinate 50 mg versus placebo the NNTs were 6.1, 7.5, and 4.0 for pain-free at two hours and headache relief at one and two hours, respectively. NNTs for sustained pain-free and sustained headache relief during the 24 hours postdose were 9.5 and 6.0, respectively . Difference in time-weighted (0-2.5 h) mean arterial pressure MAP (90% confidence interval) was 1.2 mmHg (-0.2, 2.7) between telcagepant and placebo, 4.0 mmHg (2.5, 5.5) between sumatriptan succinate and placebo, and 1.5 mmHg (0.0, 3.0) between telcagepant with sumatriptan succinate vs sumatriptan succinate alone. When coadministered with telc | ||
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