YK-4-279
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1037184-44-3 | Cat. No. | BCP13213 |
| Name | YK-4-279 | ||
| Synonyms | YK 4-279;YK4-279; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H13Cl2NO4 | M. Wt | 366.2 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 μM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks. | ||
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