Dexpramipexole
Data Sheet
For research use only. Not for human use.
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| CAS No. | 104632-28-2 | Cat. No. | BCP12512 |
| Name | Dexpramipexole | ||
| Synonyms | (R)-Pramipexole;KNS-760704; KNS 760704; KNS760704;R-(+)-Pramipexole; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C10H17N3S | M. Wt | 211.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Dexpramipexole, also known as KNS-760704 and (R)-Pramipexole, is under development for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The drug failed to show efficacy in terms of function or survival in a Phase III study of patients with ALS. Dexpramipexole is a low molecular weight, water-soluble, orally bioavailable, renally excreted compound with linear pharmacokinetics, and has been shown to be well tolerated in human subject testing. KNS-760704 is the enantiomer of pramipexole, and has been shown to improve mitochondrial function and to confer significant cellular protection in neurons under stress. A 2010 Phase II clinical trial involving 102 patients showed a slowing of ALS disease progression.[5] In January 2013, Biogen Idec announced that it was discontinuing its development of dexpramipexole in ALS due to lack of efficacy in a Phase III study. | ||
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