MI 2 MALT1 inhibitor
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1047953-91-2 | Cat. No. | BCP11666 |
| Name | MI 2 MALT1 inhibitor | ||
| Synonyms | MI-2;MI2; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H17Cl3N4O3 | M. Wt | 455.72 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MI-2 selectively killed ABC-DLBCL cell lines with CD79A/B, CARMA1, and/or MYD88 mutations but not those occurring in proteins downstream of MALT1, including those with A20 homozygous deletion or TAK1 mutation. Both MI-2 and Z-VRPR-FMK reduced nuclear c-REL to a similar extent, without affecting whole-cell levels of this protein. In both cell lines, exposure to MI-2 caused a clear reduction of nuclear c-REL whereas it did not affect p65 levels. | ||
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