AST-1306 TsOH

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02099CAS No. ：1050500-29-2Purity：98%

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Chemical Properties&Biological Activity

CAS No.	1050500-29-2	Cat. No.	BCP02099
Name	AST-1306 TsOH
Synonyms	AST-1306 TsOH;AST-1306;AST 1306;AST1306;
SMILES
Chemical Name
Formula	C24H18ClFN4O2.C7H8O3S	M. Wt	621.08
Purity	98%	Storage	Store at 4-8°C
Description	AST-1306 also ErB2 and EGFR T790M/L858R double mutant. AST-1306 is approximately 500-fold more potent than lapatinib and more than 3000-fold selective for ErbB family kinases over other kinase families including PDGFR, KDR and c-Met. AST-1306 might covalently bind to specific amino acid residues of EGFR and ErbB2. AST-1306 acts in a concentration dependent manner to significantly inhibit the growth of HIH3T3-EGFR T790M/L858R cells. AST-1306 effectively suppresses EGFR phosphorylation in HIH3T3-EGFR T790M/L858R cells. Moreover, AST-1306 blocks the growth of NCI-H1975 cells that harbor the EGFR T790M/L858R mutation in a concentration-dependent manner. AST-1306 blocks phosphorylation of EGFR and downstream pathways as well. In addition, AST-1306 dose-dependently and markedly inhibits EGF-induced EGFR phosphorylation in A549 cells. AST-1306 inhibits the phosphorylation of EGFR and ErbB2, and downstream signaling in human cancer cells including A549 cells, Calu-3 cells and SK-OV-3 cells.

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AST-1306 TsOH

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