AT13148
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1056901-62-2 | Cat. No. | BCP08961 |
| Name | AT13148 | ||
| Synonyms | AT 13148; AT-13148; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H16ClN3O | M. Wt | 313.78 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was identified utilizing high-throughput X-ray crystallography and fragment-based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK substrate phosphorylation and induction of apoptosis in both a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects both in vitro and in vivo. | ||
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