Ethambutol dihydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1070-11-7 | Cat. No. | BCP12151 |
| Name | Ethambutol dihydrochloride | ||
| Synonyms | Myambutol dihydrochloride;Emb dihydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C10H24N2O2.2ClH | M. Wt | 277.23 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Ethambutol directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutants . Ethambutol is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol. Ethambutol is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro . Ethambutol is efficient on treatment of mycobacterial-infected macrophages. | ||
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