RK-33
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1070773-09-9 | Cat. No. | BCP17697 |
| Name | RK-33 | ||
| Synonyms | RK 33;RK33; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H20N6O3 | M. Wt | 428.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | RK-33 is a novel DDX3 inhibitor for lung cancer therapy. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Importantly, RK-33 in combination with radiation induced tumor regression in multiple mouse models of lung cancer. Mechanistically, loss of DDX3 function either by shRNA or by RK-33 impaired Wnt signaling through disruption of the DDX3-β-catenin axis and inhibited non-homologous end joining-the major DNA repair pathway in mammalian somatic cells. | ||
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