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RK-33 Chemical Structure

RK-33

Data Sheet For research use only. Not for human use.
Cat. No. :BCP17697CAS No. :1070773-09-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1070773-09-9 Cat. No. BCP17697
Name RK-33
Synonyms RK 33;RK33;
SMILES
Chemical Name
Formula C23H20N6O3 M. Wt 428.44
Purity 98% Storage Store at 4-8°C
Description RK-33 is a novel DDX3 inhibitor for lung cancer therapy. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Importantly, RK-33 in combination with radiation induced tumor regression in multiple mouse models of lung cancer. Mechanistically, loss of DDX3 function either by shRNA or by RK-33 impaired Wnt signaling through disruption of the DDX3-β-catenin axis and inhibited non-homologous end joining-the major DNA repair pathway in mammalian somatic cells.
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