CYC065 free base
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1070790-89-4 | Cat. No. | BCP19571 |
| Name | CYC065 free base | ||
| Synonyms | CYC-065 free base;CYC 065 free base;CYC065; CYC-065; CYC 065; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H31N7O | M. Wt | 397.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CYC065 is an orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9) with potential antineoplastic and chemoprotective activities. CYC065 selectively binds to and inhibits the activity of CDK2, 5 and 9, which leads to inhibition of CDK2, 5 and 9-dependent cellular pathways, downregulation of genes involved in the pro-survival pathway, prevention of the activation of DNA double-strand break repair pathways, and induction of both cell cycle arrest and apoptosis. This inhibits the proliferation of CDK2/5/9-overexpressing tumor cells. In addition, CYC065 protects hematopoietic stem and progenitor cells (HSPCs), prevents myelosuppression, and preserves the function of the bone marrow. | ||
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