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PF4447943 Chemical Structure

PF4447943

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP16255CAS No. ：1082744-20-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1082744-20-4 Cat. No. BCP16255
Name PF4447943
Synonyms PF-4447943;PF 4447943;
SMILES
Chemical Name
Formula C20H25N7O2 M. Wt 395.46
Purity 98% Storage Store at 4-8°C
Description PF-04447943 increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. PF-04447943 was found to have high affinity (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11. Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer's disease.
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