Teriflunomide
Data Sheet
For research use only. Not for human use.
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| CAS No. | 108605-62-5 | Cat. No. | BCP07106 |
| Name | Teriflunomide | ||
| Synonyms | A 771726;A-771726;A 771726; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C12H9F3N2O2 | M. Wt | 270.21 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes. | ||
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