Nemorubicin

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16437CAS No. ：108852-90-0Purity：98%

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CAS No.	108852-90-0	Cat. No.	BCP16437
Name	Nemorubicin
Synonyms	Methoxymorpholinyldoxorubicin;PNU-152243;PNU 152243;PNU152243;PNU-152243A;
SMILES
Chemical Name
Formula	C32H37NO13	M. Wt	643.638
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: Methoxymorpholinyl doxorubicin (PNU 152243) is a morpholinyl analog possessing a methoxymorpholinyl group at the 3' position of the sugar moiety, which, compared with doxorubicin, appears to be less cardiotoxic and more cytotoxic against multidrug-resistant tumor cells. In this study, we report the anticancer activity of PNU 152243 on human hepatocellular carcinoma (HCC) in vitro and in vivo. The average IC50 value of PNU was 0.08 microM. Microsome-activated MMDX exhibited nanomolar IC(50) values in growth-inhibition assays of human tumor cell lines representing multiple tissues of origin: lung (A549 cells), brain (U251 cells), colon (LS180 cells), and breast (MCF-7 cells).MMDX cytotoxicity was substantially increased in Chinese hamster ovary cells after stable expression of CYP3A4 in combination with P450 reductase. in vivo: In vivo antitumor activity experiments revealed that TAO completely suppressed the ability of 90 microg/kg MMDX i.v., a dose close to the LD10, to delay