Dolastatin 10
Data Sheet
For research use only. Not for human use.
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| CAS No. | 110417-88-4 | Cat. No. | BCP12967 |
| Name | Dolastatin 10 | ||
| Synonyms | DLS 10;DLS10;DLS-10;NSC 376128;NSC376128;NSC-376128;Dolastatin-10;Dolastatin10; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C42H68N6O6S | M. Wt | 785.1 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Dolastatin 10 consists of four amino acids (in order from the amino terminus: dolavaline, valine, dolaisoleucine, and dolaproine), three unique to D. auricularia, linked to an unusual primary amine (dolaphenine, probably derived from phenylalanine) at what would otherwise be its carboxyl terminus. Monomethylauristatin E (MMAE) is a synthetic dolastatin 10 derivative with pronounced activity and toxicity. The anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E, a synthetic analog of the tubulin polymerization inhibitor dolastatin. | ||
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