Paroxetine hydrochloride hemihydrate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 110429-35-1 | Cat. No. | BCP11973 |
| Name | Paroxetine hydrochloride hemihydrate | ||
| Synonyms | BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H20FNO3.HCl.1/2H2O | M. Wt | 374.83 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM.Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression. It is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. | ||
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