Efonidipine Hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 111011-53-1 | Cat. No. | BCP16454 |
| Name | Efonidipine Hydrochloride | ||
| Synonyms | NZ-105 hydrochloride;NZ 105 hydrochloride;NZ105 hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C34H38N3O7P.HCl | M. Wt | 668.12 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | IC50 value: Target: calcium channel blocker in vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells . I(Ca(T)) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I(Ca(T)) and L-type Ca2+ channel current (I(Ca(L))) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively. in vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg twice daily and amlodipine 2.5-7.5 mg once daily for 12 weeks each in a random crossover manner. | ||
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