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A804598 Chemical Structure

A804598

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP19303CAS No. ：1125758-85-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1125758-85-1 Cat. No. BCP19303
Name A804598
Synonyms A-804598;A 804598;
SMILES
Chemical Name
Formula C19H17N5 M. Wt 315.37
Purity 98% Storage Store at 4-8°C
Description In vitro: A-804598 potently blocked IL-1β release in the THP-1 cells (IC50 of 8.5 nM). A-804598 also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50 of 8.1 nM) with similar potency as in the calcium-influx assay. In vivo: Autoradiographic analysis of coronal rat brain sections revealed that there was specific binding of [3H]-A-804598 throughout the rat brain. High levels of [3H]-A-804598 specific binding were also found in the grey matter of the L4-L6 region of the rat spinal cord.
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