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SKLB610 Chemical Structure

SKLB610

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP28112CAS No. ：1125780-41-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1125780-41-7 Cat. No. BCP28112
Name SKLB610
Synonyms SKLB-610; SKLB 610;
SMILES
Chemical Name
Formula C21H16F3N3O3 M. Wt 415.37
Purity 98% Storage Store at 4-8°C
Description SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10μM in biochemical kinase assays. SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity. Its potential to be a candidate of anticancer agent is worth being further investigated.
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