PNU-74654

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP20359CAS No. ：113906-27-7Purity：98%

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CAS No.	113906-27-7	Cat. No.	BCP20359
Name	PNU-74654
Synonyms	PNU74654; PNU 74654;
SMILES
Chemical Name
Formula	C19H16N2O3	M. Wt	320.34
Purity	98%	Storage	Store at 4-8°C
Description	PNU-74654 binds to β-catenin with a KD of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot. In NCI-H295 cells,PNU-74654 significantly decreases cell proliferation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol, testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but does not decrease cell viability.