AZD5363
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1143532-39-1 | Cat. No. | BCP04083 |
| Name | AZD5363 | ||
| Synonyms | AZD-5363; AZD 5363; Capivasertib; | ||
| SMILES | C1CN(CCC1(C(=O)NC(CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 | ||
| Chemical Name | |||
| Formula | C21H25ClN6O2 | M. Wt | 428.92 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZD5363, a novel pyrrolopyrimidine-derived compound, inhibited all AKT isoforms.AZD5363 has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent, and has potential for personalized medicine based on the genetic status of PIK3CA, PTEN, and RAS. in vitro: AZD5363, a novel pyrrolopyrimidine-derived compound, inhibited all AKT isoforms with a potency of 10 nmol/L or less and inhibited phosphorylation of AKT substrates in cells with a potency of approximately 0.3 to 0.8 μmol/L. AZD5363 monotherapy inhibited the proliferation of 41 of 182 solid and hematologic tumor cell lines with a potency of 3 μmol/L or less. | ||
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