PF 8380
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CAS No. | 1144035-53-9 | Cat. No. | BCP06651 |
Name | PF 8380 | ||
Synonyms | PF-8380;PF8380; | ||
SMILES | |||
Chemical Name | |||
Formula | C22H21Cl2N3O5 | M. Wt | 478.33 |
Purity | 98% | Storage | Store at 4-8°C |
Description | PF-8380 is an orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}. |
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