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PF 8380 Chemical Structure

PF 8380

Data Sheet For research use only. Not for human use.
Cat. No. :BCP06651CAS No. :1144035-53-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1144035-53-9 Cat. No. BCP06651
Name PF 8380
Synonyms PF-8380;PF8380;
SMILES
Chemical Name
Formula C22H21Cl2N3O5 M. Wt 478.33
Purity 98% Storage Store at 4-8°C
Description PF-8380 is an orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}.
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