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WYE-125132 Chemical Structure

WYE-125132

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02227CAS No. ：1144068-46-1Purity：98%
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  • Publications Citing of Biochempartner's WYE-125132
Front Oncol. 2020; 10: 1615. Oncotarget. 2016 May 3; 7(18): 25224–25240.
  • Chemical Properties&Biological Activity
CAS No. 1144068-46-1 Cat. No. BCP02227
Name WYE-125132
Synonyms WYE 125132;WYE125132;
SMILES
Chemical Name
Formula C26H31N7O4 M. Wt 519.61
Purity 98% Storage Store at 4-8°C
Description WYE-125132 potently and ATP-competitively inhibits recombinant mTOR kinase with IC50 of 0.19 nM and also shows the high selectivity over various PI3Ks and a panel of 230 protein kinases. [1] In vitro, WYE-125132 exhibits a significant anti-proliferative activity against a panel of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116). Besides, WYE-125132 also causes cell cycle progression, induction of apoptosis, and inhibition of protein synthesis and cell size.WYE-125132 results in a significant reduction in the synthesis of pre-tRNALeu by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively by inhibiting mTORC1. Moreover, WYE-125132 is also found to induce the dephosphorylation of Maf1 (negative regulator of Pol III transcription) and its accumulation in the nucleus.
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