Docetaxel New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01794CAS No. ：114977-28-5Purity：98%

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CAS No.	114977-28-5	Cat. No.	BCP01794
Name	Docetaxel
Synonyms	Taxotere;UK-427857;UK 427857;UK427857;RP56976; RP 56976; RP-56976;
SMILES	O=C(O[C@@H](C1[C@@]2(C)[C@@H](O)C[C@@]3([H])OC[C@]31OC(C)=O)[C@]4(O)C[C@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)C5=CC=CC=C5)=O)C(C)=C(C4(C)C)[C@@H](O)C2=O)C6=CC=CC=C6
Chemical Name
Formula	C43H53NO14	M. Wt	807.88
Purity	98%	Storage	Store at 4-8°C
Description	Docetaxel is a cytotoxic agent, especially for proliferating cells, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. Docetaxel suppresses microtubule dynamic instability as well as tread-milling, resulting in the failure of chromosomes to segregate to the daughter cells, which in turn triggers premature exit from mitosis rather than a block at this phase of the cell cycle.Docetaxel inhibits the clonogenic survival of Human cancer cell Hs746T (stomach), AGS (stomach), HeLa (cervix), CaSki (cervix), BxPC3 (pancreas), Capan-1 (pancreas) with IC50 of 1 nM, 1 nM, 0.3 nM, 0.3 nM, 0.3 nM and 0.3 nM respectively.