HLCL-61 hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1158279-20-9 | Cat. No. | BCP20660 |
| Name | HLCL-61 hydrochloride | ||
| Synonyms | HLCL61 hydrochloride; HLCL-61 HCl; HLCL61 HCl; HLCL 61 HCl; HLCL 61 hydrochloride; | ||
| SMILES | COC1=CC=CC=C1CNCC2=CC3=C(C=C2)N(CC)C4=C3C=CC=C4.[H]Cl | ||
| Chemical Name | |||
| Formula | C23H25ClN2O | M. Wt | 380.91 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia. HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML (acute myeloid leukemia) cells. As a result, significant antileukemic activity was achieved. The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it. In AML cells, PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3. | ||
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