Aurora A Inhibitor I
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1158838-45-9 | Cat. No. | BCP02101 |
| Name | Aurora A Inhibitor I | ||
| Synonyms | Aurora-A-inhibitor-I; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C31H31ClFN7O2 | M. Wt | 588.09 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Aurora A Inhibitor I is a 2,4-dianilinopyrimidine that selectively and potently inhibits Aurora A. Aurora A Inhibitor I effectively inhibits the proliferation of HCT116 and HT29 cells, with IC50 of 190 nM and 2.9 μM, respectively. The Aurora A selectivity of Aurora A Inhibitor I against Aurora B depends on a single amino acid (Thr217) of Aurora A.In KCL-22 cells, Aurora A Inhibitor I (1-5 μM) increases G2/M cell fraction, induces histone H3 serine 10 phosphorylation, and suppresses mitotic Aurora A autophosphorylation on Thr288. Aurora A Inhibitor I (0.5-5 μM) also suppresses cell proliferation in KCL-22 cells, as well as BCR-ABL-negative leukemia cell lines KG-1 and HL-60. Aurora A Inhibitor I effectively induces apoptosis in KCL-22 cells at 5 μM. In a recent study, Aurora A Inhibitor I is also found to inhibit cell growth of HCT116, HT29, and HeLa cells, with IC50 of 377.6 nM, 5.6 μM, and 416 nM. | ||
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