Lafutidine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP04476CAS No. ：118288-08-7Purity：98%

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CAS No.	118288-08-7	Cat. No.	BCP04476
Name	Lafutidine
Synonyms	Frg-8813;Frg 8813;Frg8813;
SMILES
Chemical Name
Formula	C22H29N3O4S	M. Wt	431.55
Purity	98%	Storage	Store at 4-8°C
Description	Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.It is currently marketed in Japan (Stogar) China (Lemeiting) and India (Lafaxid). It not only suppresses gastric acid secretion, but also has cytoprotective properties by the virtue of its property to induce the collagen synthesis in the gastric mucosa. It has a novel mechanism of action in addition to blocking the H2 receptors, it decreases inflammation by modulating calcitonin gene-related peptide (CGRP) and vanilloid receptors. It is also found to stimulate mucin biosynthesis and promote the restitution of damaged mucosa. Lafutidine is absorbed in the small intestine, reaches gastric cells via the systemic circulation, and then directly and rapidly binds to gastric cell histamine H2 receptors, thereby inhibiting the stimulation of cAMP and a resultant decrease in acid production (antisecretory action). It causes a sustained increase in intracellular Ca2+ ion concentration in endothelial