Nebivolol
Data Sheet
For research use only. Not for human use.
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| CAS No. | 118457-14-0 | Cat. No. | BCP07579 |
| Name | Nebivolol | ||
| Synonyms | Nebilet;Bystolic;R 065824; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H25F2NO4 | M. Wt | 405.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM. Target: β1- adrenergic receptor Nebivolol reduces cell proliferation of human coronary smooth muscle cells (haCSMCs) and endothelial cells (haECs) in a concentration- and time-dependent maner. Nebivolol treatment for 7 days causes significant reduction in cell growth of haCSMCs with IC50 of 6.1 μM, and inhibits accelerated haCSMC proliferation stimulated by growth factors PDGF-BB, bFGF, and TGFβ with IC50 values of 6 | ||
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