ALW-II-41-27
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1186206-79-0 | Cat. No. | BCP26205 |
| Name | ALW-II-41-27 | ||
| Synonyms | ALW II-41-27; ALWII-41-27; ALW-II-4127; ALW II-4127; ALWII-4127; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C32H32F3N5O2S | M. Wt | 607.69 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small-molecule inhibitor ALW-II-41-27 decreased both survival and proliferation of erlotinib-resistant tumor cells and inhibited tumor growth in vivo. ALW-II-41-27 was also effective in decreasing viability of cells with acquired resistance to the third-generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of cell survival of TKI-resistant, EGFR-mutant lung cancer and indicate that EPHA2 may serve as a useful therapeutic target in TKI-resistant tumors. | ||
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