Fruquintinib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1194506-26-7 | Cat. No. | BCP15692 |
| Name | Fruquintinib | ||
| Synonyms | HMPL-013;HMPL013;HMPL 013; | ||
| SMILES | O=C(C1=C(C)OC2=CC(OC3=C4C=C(OC)C(OC)=CC4=NC=N3)=CC=C12)NC | ||
| Chemical Name | |||
| Formula | C21H19N3O5 | M. Wt | 393.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Fruquintinib, also known as HMPL-013, is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, fruquintinib inhibits VEGF-induced phosphorylation of VEGFRs 1, 2, and 3 which may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor cell types. | ||
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