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CPI-444 Chemical Structure

CPI-444

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20881CAS No. ：1202402-40-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1202402-40-1 Cat. No. BCP20881
Name CPI-444
Synonyms CPI 444; CPI444; V81444; V-81444; V 81444; Ciforadenant;
SMILES
Chemical Name
Formula C20H21N7O3 M. Wt 407.43
Purity 98% Storage Store at 4-8°C
Description CPI-444, also known as V81444, is an orally administered antagonist of the adenosine A2A receptor. Upon oral administration, CPI-444 binds to adenosine A2A receptors expressed on the surface of immune cells, including T-lymphocytes, natural killer (NK) cells, macrophages and dendritic cells (DCs). This prevents tumor-released adenosine from interacting with the A2A receptors on these key immune surveillance cells, thereby abrogating adenosine-induced immunosuppression in the tumor microenvironment.
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