WT161
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1206731-57-8 | Cat. No. | BCP23510 |
| Name | WT161 | ||
| Synonyms | WT 161; WT-161; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C27H30N4O3 | M. Wt | 458.55 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | WT161 is a potent inhibitor of HDAC6 with an IC50 value of 0.40 nM. It is selective for HDAC6 over HDAC3 (IC50 = 51.61 nM) and induces α-tubulin acetylation, an HDAC6-dependent process, with minimal effect on global lysine acetylation. WT161 inhibits growth of patient-derived multiple myeloma cell lines with IC50 values ranging from 1.5 to 4.7 μM. WT161 enhances the cytotoxicity of bortezomib and carfilzomib against patient-derived multiple myeloma cells. It also decreases tumor size in a human MM.1S multiple myeloma mouse xenograft model when administered in combination with bortezomib at doses of 50 and 0.5 mg/kg, respectively. | ||
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