Ribociclib New
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| CAS No. | 1211441-98-3 | Cat. No. | BCP08804 |
| Name | Ribociclib | ||
| Synonyms | LEE-011; LEE 011;LEE011; | ||
| SMILES | O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5 | ||
| Chemical Name | |||
| Formula | C23H30N8O | M. Wt | 434.54 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Ribociclib, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. | ||
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