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GSK4112 Chemical Structure

GSK4112

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP16467CAS No. ：1216744-19-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1216744-19-2 Cat. No. BCP16467
Name GSK4112
Synonyms SR-6452;SR 6452;SR6452;GSK-4112;GSK 4112;
SMILES
Chemical Name
Formula C18H21ClN2O4S M. Wt 396.89
Purity 98% Storage Store at 4-8°C
Description IC50 value: 0.4 μM (EC50) Target: Rev-erbα in vitro: GSK4112 profiled as a Rev-erb agonist in cells to inhibit expression of the circadian target gene bmal1. In addition, GSK4112 repressed the expression of gluconeogenic genes in liver cells and reduced glucose output in primary hepatocytes. Therefore, GSK4112 is useful as a chemical tool to probe the function of Rev-erb in transcriptional repression, regulation of circadian biology, and metabolic pathways. Additionally, GSK4112 may serve as a starting point for design of Rev-erb chemical probes with in vivo pharmacologicalm activity.
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