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Alpelisib Chemical Structure

Alpelisib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP06730CAS No. ：1217486-61-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1217486-61-7 Cat. No. BCP06730
Name Alpelisib
Synonyms NVP-BYL719; NVP-BYL-719; NVP-BYL 719;BYL-719;BYL 719;BYL719;
SMILES O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CC(C(C)(C)C(F)(F)F)=NC=C3)S2
Chemical Name
Formula C19H22F3N5O2S M. Wt 441.47
Purity 98% Storage Store at 4-8°C
Description Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Alpelisib is equipotent against both wild type and several mutant isoforms (IC50s = 4.0-4.8 nM). eCollection 2020. Navitoclax combined with Alpelisib effectively inhibits Merkel cell carcinoma cell growth in vitro. Alpelisib Plus Letrozole Shows Promise After CDK 4/6 Inhibitor Therapy in PIK3CA-Mutated HR+/HER2- Advanced Breast Cancer.
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H-NMR HPLC
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