Dorsomorphin dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1219168-18-9 | Cat. No. | BCP06635 |
| Related Products | 866405-64-3（Dorsomorphin） | ||
| Name | Dorsomorphin dihydrochloride | ||
| Synonyms | Dorsomorphin 2HCl;BML 275 2HCl;BML275 2HCl;BML-275 2HCl; | ||
| SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl | ||
| Chemical Name | |||
| Formula | C24H25N5O | M. Wt | 472.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR and Metformin . Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition. | ||
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