BAY 87-2243
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1227158-85-1 | Cat. No. | BCP09519 |
| Name | BAY 87-2243 | ||
| Synonyms | BAY 872243; BAY872243; BAY-872243; | ||
| SMILES | FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCN(C6CC6)CC5)=NC=C4)C(C)=C3)=N2)C=C1 | ||
| Chemical Name | |||
| Formula | C26H26F3N7O2 | M. Wt | 525.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87-2243 mproves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. BAY-87-2243 markedly decreased nuclear HIF-1α expression and pimonidazole hypoxic fraction already after 3 days of drug treatment. BAY-87-2243 prior to RT significantly reduced TCD50 from 123 to 100 Gy (p=0.037). Additional BAY-87-2243 application during RT did not decrease TCD50. | ||
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