Ifebemtinib New
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| CAS No. | 1227948-82-4 | Cat. No. | BCP45896 |
| Name | Ifebemtinib | ||
| Synonyms | BI853520;IN10018;BI-853520;IN-10018;BI8 53520;IN 10018; | ||
| SMILES | CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2F)NC3=NC=C(C(=N3)OC4=CC=CC5=C4C(=O)N(C5)C)C(F)(F)F)OC | ||
| Chemical Name | |||
| Formula | C28H28F4N6O4 | M. Wt | 588.55 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Protein Tyrosine Kinase 2 Inhibitor IN10018 is an orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase protein tyrosine kinase 2 (focal adhesion kinase 1; FAK1; FAK: PTK2) with potential antineoplastic activity. Upon oral administration, IN10018 targets and inhibits, in an adenosine triphosphate (ATP)-competitive manner, PTK2. This prevents PTK2-mediated downstream signaling and inhibits migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells. The cytoplasmic tyrosine kinase PTK2, a signal transducer for integrins overexpressed in various tumor cell types, is involved in tumor cell invasion, migration and proliferation. | ||
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