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AM095 Chemical Structure

AM095

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP09983CAS No. ：1228690-36-5Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1228690-36-5 Cat. No. BCP09983
Name AM095
Synonyms AM-095; AM 095;
SMILES
Chemical Name
Formula C27H24N2O5 M. Wt 456.49
Purity 98% Storage Store at 4-8°C
Description AM095 is an LPA1 receptor antagonist with good oral exposure and antifibrotic activity in rodent models. In vitro, AM095 inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively, and exhibited no LPA1 agonism. In functional assays, AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA? (IC50= 778 nM) and human A2058 melanoma cells (IC50 = 233 nM). Another study showed that LPA/LPA1 pathway inhibition has the potential to be an effective new therapeutic strategy for systemic sclerosis (SSc), and that LPA1 is an attractive pharmacologic target in dermal fibrosis.
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