BMS-935177
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1231889-53-4 | Cat. No. | BCP25754 |
| Name | BMS-935177 | ||
| Synonyms | BMS935177;BMS 935177; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C31H26N4O3 | M. Wt | 502.57 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BMS-935177 a potent BTK inhibitor with improved kinase selectivity and superior oral exposure in multiple species. should provide useful clinical efficacy in autoimmune diseases. BMS-935177 inhibited calcium flux in human Ramos B cells (IC50 = 27 nM) and inhibited CD69 surface expression in peripheral B cells stimulated with anti-IgM and anti-IgG. On the basis of in vitro potency, in vivo activity, and pharmacokinetic profile, BMS-935177 was selected for further studies in support of clinical development. | ||
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