Abemaciclib mesylate New
Data Sheet
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| CAS No. | 1231930-82-7 | Cat. No. | BCP07762 |
| Name | Abemaciclib mesylate | ||
| Synonyms | Bamaciclib Mesylate;Abemaciclib methanesulfonate;LY2835219 Mesylate;LY-2835219 Mesylate; LY 2835219 Mesylate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H36F2N8O3S | M. Wt | 602.7 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Abemaciclib Mesylate is the mesylate salt of abemaciclib, an orally available cyclin-dependent kinase (CDK) inhibitor that targets the cyclin D1-CDK4 and cyclin D3-CDK6 cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. | ||
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