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APY0201
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CAS No. | 1232221-74-7 | Cat. No. | BCP15146 |
Name | APY0201 | ||
Synonyms | APY-0201;APY 0201; | ||
SMILES | |||
Chemical Name | |||
Formula | C23H23N7O | M. Wt | 413.48 |
Purity | 98% | Storage | Store at 4-8°C |
Description | APY0201 works differently from anti-IL-12/23 antibodies and acts by inhibiting production of these proinflammatory cytokines with characteristic selectivity over other cytokines, including tumor necrosis factor-alpha (TNF-α). In stimulated thioglycollate-induced mouse peritoneal exudate cells (TG-PEC), APY0201 strongly inhibited IL-12p70 and IL-12p40 production, with IC50 values of 8.4 and 16 nM, respectively. APY0201 also inhibited IL-12p40 at 99 nM in human PBMC. APY0201 showed significant selectivity for the production of IL-12p70 and IL-12p40 over TNF-α, and this selectivity was maintained across species. in vivo: Oral APY0201 at a 30 mg/kg dose showed significant reduction of IL-12p70 production (78% inhibition relative to that of the vehicle control), which implied that the inhibitory potential of APY0201 against IL-12 was confirmed in the animal experiment. |
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