APY0201

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP15146CAS No. ：1232221-74-7Purity：98%

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CAS No.	1232221-74-7	Cat. No.	BCP15146
Name	APY0201
Synonyms	APY-0201;APY 0201;
SMILES
Chemical Name
Formula	C23H23N7O	M. Wt	413.48
Purity	98%	Storage	Store at 4-8°C
Description	APY0201 works differently from anti-IL-12/23 antibodies and acts by inhibiting production of these proinflammatory cytokines with characteristic selectivity over other cytokines, including tumor necrosis factor-alpha (TNF-α). In stimulated thioglycollate-induced mouse peritoneal exudate cells (TG-PEC), APY0201 strongly inhibited IL-12p70 and IL-12p40 production, with IC50 values of 8.4 and 16 nM, respectively. APY0201 also inhibited IL-12p40 at 99 nM in human PBMC. APY0201 showed significant selectivity for the production of IL-12p70 and IL-12p40 over TNF-α, and this selectivity was maintained across species. in vivo: Oral APY0201 at a 30 mg/kg dose showed significant reduction of IL-12p70 production (78% inhibition relative to that of the vehicle control), which implied that the inhibitory potential of APY0201 against IL-12 was confirmed in the animal experiment.