VE-821
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1232410-49-9 | Cat. No. | BCP02617 |
| Name | VE-821 | ||
| Synonyms | VE821;VE 821; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H16N4O3S | M. Wt | 368.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | VE-821 shows excellent selectivity for ATR with minimal cross-reactivity against the related PIKKs ATM, DNA-PK, mTOR and PI3K (Kis of 16 μM, 2.2 μM, >1 μM and 3.9 μM, respectively. VE-821 alone commits a large fraction of cancer cell populations to death, but it only reversibly limits cell cycle progression in normal cells, with minimal death or long-term detrimental effects. VE-821 along with cisplatin treatment shows the most marked synergy.VE-821 inhibits H2AX cell growth with IC50 of 800 nM. | ||
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