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PF-05089771 Chemical Structure

PF-05089771

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP07066CAS No. ：1235403-62-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1235403-62-9 Cat. No. BCP07066
Name PF-05089771
Synonyms PF-05089771; PF 05089771; PF05089771; PF-05089771; PF05089771; PF 05089771;
SMILES
Chemical Name
Formula C18H12Cl2FN5O3S2 M. Wt 500.34
Purity 98% Storage Store at 4-8°C
Description PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV. PF-05089771 exhibits a slow onset of block that is depolarization and concentration dependent, with a similarly slow recovery from block. Human hereditary gain- or loss-of-pain disorders have demonstrated an essential role of Nav1.7 sodium channels in the sensation of pain, thus making this channel an attractive target for new pain therapies.
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