TRX-0237 mesylate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1236208-20-0 | Cat. No. | BCP16840 |
| Name | TRX-0237 mesylate | ||
| Synonyms | Leucomethylene blue Mesylate； TRX-0237; TRX 0237; TRX0237; LMTX;L-MTx; LMT-X; Leuco-MTx; Methylene blue mesylate;Methylene blue leuco base mesylate salt; | ||
| SMILES | CN(C)C1=CC(SC2=CC(N(C)C)=CC=C2N3)=C3C=C1.CS(=O)(O)=O.CS(=O)(O)=O | ||
| Chemical Name | |||
| Formula | C18H27N3O6S3 | M. Wt | 477.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TRX-0237 mesylate, also known as LMTX, is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a replacement formulation for Rember®, the first company's first proprietary formulation of methylthioninium chloride (MTC). Both TRx 0237 and Rember are purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria, as well as for methemoglobinemia and other conditions. TRx 0237 and Rember share the same mode of action, but TRx 0237 has been designed as a stabilized, reduced form of MTC to improve the drug's absorption, bioavailability, and tolerability. | ||
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