UNC0321
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1238673-32-9 | Cat. No. | BCP12391 |
| Name | UNC0321 | ||
| Synonyms | UNC-0321;UNC 0321; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C27H45N7O3 | M. Wt | 515.69 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | It was found that replacing the 5-carbon chain in compound 13 with an ethoxyethyl chain resulted in compound 29{UNC0321} (IC50 = 6 nM (CLOT) and 9 nM (ECSD)), the most potent G9a inhibitor to date. 29 had a Morrison Ki of 63 pM and was about 40-fold more potent than 10 (Morrison Ki = 2.6 nM) and 250-fold more potent than 3a (Morrison Ki = 16 nM) in this G9a MCE assay.UNC0321 potentially useful small molecule tools for the biomedical research community to investigate the biology of G9a and its role in chromatin remodeling as well as PTMs of other proteins. | ||
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