Tubastatin A trifluoroacetate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1239262-52-2 | Cat. No. | BCP02536 |
| Name | Tubastatin A trifluoroacetate | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H22F3N3O4 | M. Wt | 431.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tubastatin A preferentially induces α-tubulin hyperacetylation at 2.5 μM. Slight induction of histone hyperacetylation is seen for Tubastatin A at 10 μM. Tubastatin A displays dose-dependent protection against homocysteic acid-induced neuronal cell death starting at 5 μM with near complete protection at 10 μM. [1] Tubastatin A (10 μM) induces an increase in acetylated-α-tubulin levels and the restoration of primary cilia expression in the cholangiocarcinoma cell lines (18-fold); and the restoration of primary cilia correlated with downregulated Hedgehog (Hh) and MAPK signaling pathways, as well as decreased cell proliferation rates (in average by 50%) and invasion (by 40%). [2] Tubastatin A shows significant inhibition of TNF-α and IL-6 in LPS stimulated human THP-1 macrophages with an IC50 of 272 nM and 712 nM. Tubastatin A inhibits nitric oxide (NO) secretion in murine Raw 264.7 macrophages dose depenndently with an IC50 of 4.2 μM. | ||
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