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Topotecan Chemical Structure

Topotecan

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP08995CAS No. ：123948-87-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 123948-87-8 Cat. No. BCP08995
Name Topotecan
Synonyms NSC 609699 NSC-609699 NSC609699; SKF S104864A;
SMILES
Chemical Name
Formula C23H23N3O5 M. Wt 421.45
Purity 98% Storage Store at 4-8°C
Description Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.
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