CU-CPT-8m
Data Sheet
For research use only. Not for human use.
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| CAS No. | 125079-83-6 | Cat. No. | BCP29123 |
| Name | CU-CPT-8m | ||
| Synonyms | CPD1578; CPD 1578; CPD-1578;CU-CPT8m; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C14H12N4O | M. Wt | 252.28 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CU-CPT8m is a Toll-like receptor 8 (TLR8) specific small-molecule inhibitor that exerts “potent anti-inflammatory effects” on the tissue of patients with arthritis, osteoarthritis and Still’s disease, a rare autoimmune illness. CU-CPT8m has a Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity; shows no effect on TLR1/2/6, TLR3, TLR4, TLR5, TLR7 and TLR9; inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells with IC50 of 90 nM, also abolishes the elevation of TNF-α and IL-8 mRNA levels; suppresses the proinflammatory cytokine production in multiple human primary cells derived from different patients. | ||
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